Our Work - Evidence Based Health Care - Treat Mental Illness - Promote Mental Health - Digital Health Assessment and Innovation - Intervention for Depression - Digital Phenotyping and Therapeutics - The Center for Digital Mental Health

Our Work

The Center integrates digital technologies and artificial intelligence to transform how mental health risk is identified, monitored, and treated.

Our work is supported by investigator-initiated industry sponsorships, federal (NIH) and foundation grants, and philanthropy. The Center focuses on advancing technology-enabled and AI-informed approaches to improve the assessment, prevention, and treatment of mental health conditions. Our research emphasizes the following key areas:

Developing and Testing New Technologies

  • PRECISION ASSESSMENT:
    We use ecologically valid, data-driven approaches, including digital phenotyping, passive sensing, wearable biosensors, and artificial intelligence, to predict risk, detect early warning signals, and identify optimal points for mental health intervention across diverse populations and real-world settings.
  • EVIDENCE-BASED DIGITAL TOOLS AND TREATMENT:
    We develop and rigorously test novel digital and AI-enabled solutions to enhance access to evidence-based mental health tools and interventions. Our work emphasizes user-centered and community-engaged design, leveraging data science and machine learning to understand how, for whom, and under what conditions digital interventions are most effective. A core priority is inclusion, ensuring that digital and AI-driven solutions are equitable, accessible, and appropriate for all individuals.
  • CUTTING EDGE METHODS:
    We advance the responsible integration of artificial intelligence across the patient care journey, from risk assessment and clinical decision support to treatment delivery and outcome prediction. Our work aims to enhance treatment accessibility, personalization, flexibility, and effectiveness while maintaining transparency, clinical relevance, and ethical rigor.

Implementation of

Evidence-based, scalable digital and data-informed health solutions to expand the mental health care system’s capacity and reach, reduce disparities in care, and address the youth mental health crisis across K-12 and higher education.

 

Sharing Knowledge

Developing and disseminating training and educational opportunities in evidence-based, scalable, and data-informed mental health practices.

  • Psychology training programs: Learn more about training opportunities for pre-doctoral interns and post-doctoral fellows in psychology through Mass General Brigham training programs, see training.
  • Clinician education: For continuing education and professional trainings, visit the MGH Psychiatry Academy.
  • Consultation and Collaboration: For information about consultations with our team, see consulting.

Selected Publications

Jonathan GK, Miyares P, Hoeppner SS, Velazquez S, Jacoby RJ, Greenberg J, Sprich S, Wilhelm S. Disseminating cognitive-behavioral therapy for body dysmorphic disorder: Evaluating the efficacy of online provider training. Internet Interv 2026; 44: 100925.

Sung J, Zainal N, Greenberg J, Curtiss J, Jacoby R, Weingarden H, Wilhelm S. Executive Functioning as a Predictor of Digital Cognitive Behavioral Therapy Outcomes for Body Dysmorphic Disorder: A Machine Learning Approach. Cognitive Ther Res 2026.

Jonathan GK, Sung JY, Arcese HT, Holz P, Bentley KH, Bernstein EE, Weingarden HM, Greenberg JL, Harrison OT, Wilhelm S. Identifying evidence-based strategies in a digital mental health intervention for depression: A qualitative content analysis. JMIR Mental Health 2026 (Preprint).

Wilhelm S, Greenberg JL, Jacoby RJ, Weingarden H, Hoeppner SS, Klare D, Snorrason I, Jaroszewski AC, McCoy TH, Harrison O.  A Randomized Clinical Trial of App Cognitive Behavior Therapy vs. HealthWatch for Obsessive Compulsive Disorder.  npj Digital Med 2025; 8(800). PubMed Central PMCID: PMC12753652.

Weingarden H, Holstein V, Jonathan GK, Armey M, Onnela JP, Wilhelm S. Low-burden detection of clinical worsening in body dysmorphic disorder using smartphone sensor and demographic data. Behav Ther 2025.

Weingarden H, Jaroszewski A, Armey M, Hoeppner BB, Armstrong CH, Onnela JP, Wilhelm S. Predicting concurrent and short-term desire and intent to attempt suicide among people with body dysmorphic disorder using ecological momentary assessment of anxiety and shame. J Psychopathol Clin Sci 2025.

Jaroszewski AC, Bailen N, Ipek SI, Greenberg JL, Hoeppner SS, Weingarden H, Snorrason I, Wilhelm S. The prevalence and incidence of suicidal thoughts and behavior in a smartphone-delivered treatment trial for body dysmorphic disorder: Cohort Study. JMIR Mental Health. 2025 May 6;12(1):e63605.

Bernstein EE, Daniel KE, Miyares PE, Hoeppner S, Bentley KH, Snorrason I, Fisher LB, Greenberg JL, Weingarden H, Harrison O, Wilhelm S. Patterns of skills review in smartphone Cognitive Behavioral Therapy for Depression: Observational study of intervention content use. JMIR Ment Health 2025; 12:e63497. PMCID: PMC11894344.

Jonathan GK, Guo Q, Arcese H, Evins AE, Wilhelm S. Digital integrated interventions for comorbid depression and substance use disorder: narrative review and content analysis. JMIR 2025;12. PMCID: PMC12102630.

Barbieri JS, Noe NH, Bensellam N, Holz P, Galvao De Oliveira Wafae, B, Anshelevich EE, Williams J, Snorrason I, Weingarden H, Harrison O, Wilhelm S. A Trial of Coach-Supported, Smartphone-Delivered Cognitive Behavioral Therapy for Psoriasis With Comorbid Depression. JPPA 2025. PMCID: PMC12507800.

Snorrason I, Hoeppner SS, Klare D, Weingarden H, Greenberg JL, Berger-Gutierrez RM, Bernstein EE, Vanderkruik RC, Harrison O, Wilhelm S.  Long-term outcomes of smartphone-delivered cognitive behavior therapy for body dysmorphic disorder: A one-year naturalistic follow-up.  Internet Interv 2025; 39: 100803

Bernstein EE, Jaroszewski AC, Jacoby RJ, Bailen NH, Ragan J, Usmani A, Wilhelm S.  Feasibility of using ChatGPT to generate exposure hierarchies for treating obsessive compulsive disorder. Behav Ther 2025; 56(4):680-688. PMCID: PMC12912708.

Rief W, Asmundson GJ, Bryant RA, Clark DM, Ehlers A, Holmes EA, McNally RJ, Neufeld CB, Wilhelm S, Jaroszewski AC, Berg M. The future of psychological treatments: The Marburg Declaration. Clinical Psychology Review. 2024 Jun 1;110:102417.

Wilhelm S, Bernstein E, Bentley K, Snorrason I, Hoeppner S, Klare D, Greenberg J, Weingarden H, McCoy T, Harrison O.  Feasibility, Acceptability, and Preliminary Efficacy of a Smartphone App–Led Cognitive Behavioral Therapy for Depression Under Therapist Supervision: Open Trial.  JMIR Ment Health 2024;11:e53998.

Bernstein EE, *Greenberg JL, Weingarden H, Williams J, Quist R, Snorrason I, Curtiss J, Wilhelm S. The use of coaching in smartphone app-based cognitive behavioral therapy for body dysmorphic disorder. Internet Interv 2024; 36:100743.

Greenberg JL, Weingarden H, Hoeppner SS, Berger-Gutierrez RM, Klare D, Snorrason I, Costilla-Reyes O, Talbot M, Daniel KE, Vanderkruik RC, Solar-Lezama A, Harrison O, Wilhelm S. Predicting response to a smartphone-based cognitive-behavioral therapy for body dysmorphic disorder. J Affect Disord 2024; 355:106-114. PMCID: PMC11044861.

Wilhelm S, Bernstein E, Bentley K, Snorrason I, Hoeppner S, Klare D, Greenberg J, Weingarden H, McCoy T, Harrison O.  Feasibility, Acceptability, and Preliminary Efficacy of a Smartphone App–Led Cognitive Behavioral Therapy for Depression Under Therapist Supervision: Open Trial.  JMIR Ment Health 2024;11:e53998. PubMed Central PMCID: PMC11040445.

Weingarden H, Garriga Calleja R, Greenberg JL, Snorrason I, Matic A, Quist R, Harrison O, Hoeppner SS, Wilhelm S. Characterizing observed and effective behavioral engagement with smartphone cognitive behavioral therapy for body dysmorphic disorder: A methods roadmap and use case. Internet Interv. 2023 Apr;32:100615. PubMed Central PMCID: PMC10031461.

Bernstein EE, Weingarden H, Greenberg JL, Williams J, Hoeppner SS, Snorrason I, Phillips KA, Harrison O, Wilhelm S. Credibility and expectancy of smartphone-based cognitive behavioral therapy among adults with body dysmorphic disorder. JOCRD 2023; 36. PMCID: PMC10835574.

Hiranandani S, Ipek S, Wilhelm S, Greenberg J. Digital mental health interventions for Obsessive Compulsive and Related Disorders: A brief review of evidence-based interventions and future directions. JOCRD 2023; 36.

Wilhelm S, Weingarden H, Greenberg JL, Hoeppner SS, Snorrason I, Bernstein EE, McCoy TH, & Harrison O. Efficacy of App-based Cognitive Behavioral Therapy for Body Dysmorphic Disorder with Coach Support: Initial Randomized Controlled Clinical Trial. Psychother Psychosom.  2022;91(4):277-285. PMCID: PMC9394457.

Jacobson NC, Summers B, Wilhelm S. Digital Biomarkers of Social Anxiety Symptom Severity: Digital Phenotyping using Passive Smartphone Sensors.  JMIR 2020; 22(5):e16875.  PMCID: PMC7293055.

Wilhelm S, Weingarden H, Greenberg JL, McCoy TH, Ladis I, Summers BJ, Matic A, Harrison O. Development and Pilot Testing of a Cognitive-Behavioral Therapy Digital Service for Body Dysmorphic Disorder. Behav Ther. 2020 Jan;51(1):15-26. PubMed PMID: 32005333.

Weingarden H, Matic A, Garriga Calleja R, Greenberg JL, Harrison O, Wilhelm S. Optimizing smartphone cognitive behavioral therapy for body dysmorphic disorder using passive smartphone data: Initial insights from an open pilot trial. JMIR Mhealth Uhealth. 2020; 8: e16350. doi: 10.2196/16350

Wilhelm S, Weingarden H, Ladis I, Braddick V, Shin J, Jacobson NC. Cognitive-behavioral therapy in the digital age: Presidential Address. Behav Ther 2020; 51(1): 1-14. https://doi.org/10.1016/j.beth.2019.08.001 PMCID: PMC7155747.

Jacobson NC, Wilhelm S, Weingarden H. Using Digital Phenotyping to Accurately Detect Depression Severity.  J Nerv Ment Dis 2019; 207(10): 893–896.

Jacobson NC, Weingarden H, Wilhelm S. Digital biomarkers of mood disorders and symptom change. NPJ Digit Med. 2019 Feb 1;2:3. doi: 10.1038/s41746-019-0078-0. PMID: 31304353; PMCID: PMC6550284.

Wilhelm S, Phillips KA, Greenberg JL, O’Keefe SM, Hoeppner SS, Keshaviah A, Sarvode-Mothi S, Schoenfeld DA. Efficacy and Posttreatment Effects of Therapist-Delivered Cognitive Behavioral Therapy vs Supportive Psychotherapy for Adults with Body Dysmorphic Disorder: A Randomized Clinical Trial. JAMA Psychiat 2019; 76(4): 363-373.  PMCID: PMC6450292.

 

 

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